Internal anal sphincter atrophy in patients with systemic sclerosis

Thoua, Nora M, Schizas, Alexis, Forbes, Alastair, Denton, Christopher P and Emmanuel, Anton V (2011) Internal anal sphincter atrophy in patients with systemic sclerosis. Rheumatology, 50 (9). pp. 1596-602. ISSN 1462-0324

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Abstract

SSc is a connective tissue, multisystem disorder of unknown aetiology. The gastrointestinal tract (GIT) is affected in up to 90% of patients. The exact pathophysiology of GIT involvement is not known, but it is related to both neurogenic and myogenic abnormalities as well as possible vascular and ischaemic changes. Thinning of the internal anal sphincter (IAS) has been demonstrated in SSc with faecal incontinence. We aimed to investigate anal sphincter structure in patients with SSc.

Item Type: Article
Uncontrolled Keywords: adult,aged,anal canal,case-control studies,endosonography,fecal incontinence,female,humans,intestinal diseases,male,manometry,middle aged,questionnaires,scleroderma, systemic
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Nutrition
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 11:58
Last Modified: 25 Jul 2018 09:57
URI: https://ueaeprints.uea.ac.uk/id/eprint/49820
DOI: 10.1093/rheumatology/ker153

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