Peculiar antibody reactivity to human connexin 37 and its microbial mimics in patients with Crohn's disease

Koutsoumpas, Andreas, Polymeros, Dimitrios, Tsiamoulos, Zacharias, Smyk, Daniel, Karamanolis, George, Triantafyllou, Konstantinos, Rigopoulou, E I, Forbes, Alastair, Vergani, Diego, Bogdanos, Dimitrios P and Ladas, Spiros D (2011) Peculiar antibody reactivity to human connexin 37 and its microbial mimics in patients with Crohn's disease. Journal of Crohn's & Colitis, 5 (2). pp. 101-9. ISSN 1876-4479

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Abstract

We found that pooled Crohn's disease (CD) sera strongly react with a human gap-junction connexin 37 (Cx37) peptide and tested for anti-Cx37 antibody reactivity in sera from CD patients and controls. We also investigated whether peptide-recognition is due to Cx37/microbial molecular mimicry.

Item Type: Article
Additional Information: Copyright © 2010 Elsevier B.V. All rights reserved.
Uncontrolled Keywords: adult,antigen-antibody reactions,bacterial proteins,connexins,crohn disease,enterovirus b, human,enterovirus c, human,female,humans,lactococcus lactis,male,middle aged,molecular mimicry,sequence homology, amino acid,viral proteins
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Nutrition
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 11:50
Last Modified: 29 Aug 2018 10:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/49784
DOI: 10.1016/j.crohns.2010.10.009

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