Anti-tumor necrosis factor-alpha-loaded microspheres as a prospective novel treatment for Crohn's disease fistulae

Foong, Keen Shawn, Patel, Rishni, Forbes, Alastair ORCID: https://orcid.org/0000-0001-7416-9843 and Day, Richard M (2010) Anti-tumor necrosis factor-alpha-loaded microspheres as a prospective novel treatment for Crohn's disease fistulae. Tissue Engineering. Part C, Methods, 16 (5). pp. 855-64. ISSN 1937-3392

Full text not available from this repository. (Request a copy)

Abstract

Antibodies to tumor necrosis factor alpha (TNF-α) have been successful in treating perianal fistulae in Crohn's disease, but current modes of delivery are limited. Microspheres are currently being assessed as scaffolds for tissue engineering and drug delivery devices. The aim of this study was to produce anti-TNF-α antibody-encapsulated microspheres using thermally induced phase separation (TIPS) and to characterize their behavior.

Item Type:	Article
Uncontrolled Keywords:	antibodies, monoclonal,cell line,crohn disease,enzyme-linked immunosorbent assay,humans,lactic acid,microscopy, electron, scanning,microspheres,polyglycolic acid,prospective studies,rectal fistula,tumor necrosis factor-alpha
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	Pure Connector
Date Deposited:	06 Aug 2014 10:44
Last Modified:	21 Oct 2022 00:02
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49779
DOI:	10.1089/ten.TEC.2009.0599

Actions (login required)

View Item