Anti-tumor necrosis factor-alpha-loaded microspheres as a prospective novel treatment for Crohn's disease fistulae

Foong, Keen Shawn, Patel, Rishni, Forbes, Alastair and Day, Richard M (2010) Anti-tumor necrosis factor-alpha-loaded microspheres as a prospective novel treatment for Crohn's disease fistulae. Tissue Engineering. Part C, Methods, 16 (5). pp. 855-64. ISSN 1937-3392

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Abstract

Antibodies to tumor necrosis factor alpha (TNF-α) have been successful in treating perianal fistulae in Crohn's disease, but current modes of delivery are limited. Microspheres are currently being assessed as scaffolds for tissue engineering and drug delivery devices. The aim of this study was to produce anti-TNF-α antibody-encapsulated microspheres using thermally induced phase separation (TIPS) and to characterize their behavior.

Item Type: Article
Uncontrolled Keywords: antibodies, monoclonal,cell line,crohn disease,enzyme-linked immunosorbent assay,humans,lactic acid,microscopy, electron, scanning,microspheres,polyglycolic acid,prospective studies,rectal fistula,tumor necrosis factor-alpha
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Nutrition
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 11:44
Last Modified: 25 Jul 2018 09:56
URI: https://ueaeprints.uea.ac.uk/id/eprint/49779
DOI: 10.1089/ten.TEC.2009.0599

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