Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease

Prescott, Natalie J, Dominy, Katherine M, Kubo, Michiaki, Lewis, Cathryn M, Fisher, Sheila A, Redon, Richard, Huang, Ni, Stranger, Barbara E, Blaszczyk, Katarzyna, Hudspith, Barry, Parkes, Gareth, Hosono, Naoya, Yamazaki, Keiko, Onnie, Clive M, Forbes, Alastair ORCID: https://orcid.org/0000-0001-7416-9843, Dermitzakis, Emmanouil T, Nakamura, Yusuke, Mansfield, John C, Sanderson, Jeremy, Hurles, Matthew E, Roberts, Roland G and Mathew, Christopher G (2010) Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease. Human Molecular Genetics, 19 (9). pp. 1828-1839. ISSN 0964-6906

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Abstract

DNA polymorphisms in a region on chromosome 5q33.1 which contains two genes, immunity related GTPase related family, M (IRGM) and zinc finger protein 300 (ZNF300), are associated with Crohn's disease (CD). The deleted allele of a 20 kb copy number variation (CNV) upstream of IRGM was recently shown to be in strong linkage disequilibrium (LD) with the CD-associated single nucleotide polymorphisms and is itself associated with CD (P

Item Type:	Article
Uncontrolled Keywords:	asian continental ancestry group,base sequence,crohn disease,dna copy number variations,dna primers,european continental ancestry group,gtp-binding proteins,genetic predisposition to disease,genetic variation,genotype,great britain,haplotypes,humans,indel mutation,logistic models,molecular sequence data,oligonucleotide array sequence analysis,promoter regions, genetic,reverse transcriptase polymerase chain reaction,sequence analysis, dna
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	Pure Connector
Date Deposited:	06 Aug 2014 10:56
Last Modified:	20 Oct 2022 19:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49773
DOI:	10.1093/hmg/ddq041

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