Assessment of polymer/bioactive glass-composite microporous spheres for tissue regeneration applications

Keshaw, Hussila, Georgiou, George, Blaker, Jonny J, Forbes, Alastair, Knowles, Jonathan C and Day, Richard M (2009) Assessment of polymer/bioactive glass-composite microporous spheres for tissue regeneration applications. Tissue engineering. Part A, 15 (7). pp. 1451-61. ISSN 1937-335X

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Abstract

Conformable scaffold materials capable of rapid vascularization and tissue infiltration would be of value in the therapy of inaccessible wounds. Microporous spheres of poly(D,L-lactide-co-glycolide) (PLGA) containing bioactive glass (BG) were prepared using a thermally induced phase separation (TIPS) technique, and the bioactivity, in vitro degradation, and tissue integration of the microporous spheres were assessed. Microporous spheres containing 10% (w/w) BG stimulated a significant increase in vascular endothelial growth factor secretion from myofibroblasts consistently over a 10-day period (p

Item Type: Article
Uncontrolled Keywords: animals,cell survival,cells, cultured,compressive strength,fibroblasts,glass,humans,implants, experimental,lactic acid,materials testing,microscopy, electron, scanning,microspheres,polyglycolic acid,porosity,rats,regeneration,subcutaneous tissue,tissue engineering,vascular endothelial growth factor a
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 11:48
Last Modified: 11 Apr 2019 15:42
URI: https://ueaeprints.uea.ac.uk/id/eprint/49767
DOI: 10.1089/ten.tea.2008.0203

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