Assessment of polymer/bioactive glass-composite microporous spheres for tissue regeneration applications

Keshaw, Hussila, Georgiou, George, Blaker, Jonny J, Forbes, Alastair ORCID: https://orcid.org/0000-0001-7416-9843, Knowles, Jonathan C and Day, Richard M (2009) Assessment of polymer/bioactive glass-composite microporous spheres for tissue regeneration applications. Tissue Engineering: Part A, 15 (7). pp. 1451-61. ISSN 1937-335X

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Abstract

Conformable scaffold materials capable of rapid vascularization and tissue infiltration would be of value in the therapy of inaccessible wounds. Microporous spheres of poly(D,L-lactide-co-glycolide) (PLGA) containing bioactive glass (BG) were prepared using a thermally induced phase separation (TIPS) technique, and the bioactivity, in vitro degradation, and tissue integration of the microporous spheres were assessed. Microporous spheres containing 10% (w/w) BG stimulated a significant increase in vascular endothelial growth factor secretion from myofibroblasts consistently over a 10-day period (p

Item Type:	Article
Uncontrolled Keywords:	animals,cell survival,cells, cultured,compressive strength,fibroblasts,glass,humans,implants, experimental,lactic acid,materials testing,microscopy, electron, scanning,microspheres,polyglycolic acid,porosity,rats,regeneration,subcutaneous tissue,tissue engineering,vascular endothelial growth factor a
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	Pure Connector
Date Deposited:	06 Aug 2014 10:48
Last Modified:	21 Oct 2022 00:02
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49767
DOI:	10.1089/ten.tea.2008.0203

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