Detection of muramyl dipeptide-sensing pathway defects in patients with Crohn's disease

van Heel, David A, Hunt, Karen A, King, Kathy, Ghosh, Subrata, Gabe, Simon M, Mathew, Christopher G, Forbes, Alastair ORCID: https://orcid.org/0000-0001-7416-9843 and Playford, Raymond J (2006) Detection of muramyl dipeptide-sensing pathway defects in patients with Crohn's disease. Inflammatory Bowel Diseases, 12 (7). pp. 598-605. ISSN 1078-0998

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Abstract

Crohn's disease is strongly associated with double mutations in NOD2/CARD15. Three common mutations (Arg702Trp, Gly908Arg, Leu1007fs) impair innate immune responses to bacterial muramyl dipeptide. Rare NOD2 variants occur, but it is difficult to both identify them and assess their functional effect. We assessed the true frequency of defective muramyl dipeptide sensing in Crohn's disease and developed a rapid diagnostic assay.

Item Type:	Article
Uncontrolled Keywords:	acetylmuramyl-alanyl-isoglutamine,crohn disease,cytokines,enzyme-linked immunosorbent assay,genotype,heterozygote,humans,immunosuppressive agents,inflammation,interleukin-1beta,interleukin-8,lipopolysaccharides,monocytes,mutation,sensitivity and specificity
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	Pure Connector
Date Deposited:	06 Aug 2014 10:58
Last Modified:	21 Oct 2022 00:00
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49665
DOI:	10.1097/01.ibd.0000225344.21979.89

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