Intestinal growth in parenterally-fed rats induced by the combined effects of glucagon-like peptide 2 and epidermal growth factor

Kitchen, Paul A, Goodlad, Robert A, FitzGerald, Anthony J, Mandir, Nikki, Ghatei, Mohammed A, Bloom, Stephen R, Berlanga-Acosta, Jorge, Playford, Raymond J, Forbes, Alastair and Walters, Julian R F (2005) Intestinal growth in parenterally-fed rats induced by the combined effects of glucagon-like peptide 2 and epidermal growth factor. Journal of Parenteral and Enteral Nutrition, 29 (4). pp. 248-54. ISSN 0148-6071

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Abstract

Parenteral nutrition and the absence of luminal feeding result in impaired intestinal growth and differentiation of enterocytes. Glucagon-like peptide 2 (GLP-2) and epidermal growth factor (EGF) have each been shown to have trophic effects on the intestine, and thus have the potential to benefit patients fed parenterally, such as those with intestinal failure from short bowel syndrome. We report studies aimed to determine whether there may be synergistic effects of these 2 peptides.

Item Type: Article
Uncontrolled Keywords: adaptation, physiological,animals,cell division,disease models, animal,drug synergism,epidermal growth factor,glucagon-like peptide 2,glucagon-like peptides,intestine, small,male,organ size,parenteral nutrition,peptides,random allocation,rats,rats, wistar,short bowel syndrome
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Nutrition
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 11:48
Last Modified: 25 Jul 2018 09:54
URI: https://ueaeprints.uea.ac.uk/id/eprint/49635
DOI:

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