Randomized, placebo-controlled trial of gastric acid-lowering therapy on duodenal polyposis and relative adduct labeling in familial adenomatous polyposis

Wallace, M H, Forbes, A, Beveridge, I G, Spigelman, A D, Hewer, A, Venitt, S and Phillips, R K (2001) Randomized, placebo-controlled trial of gastric acid-lowering therapy on duodenal polyposis and relative adduct labeling in familial adenomatous polyposis. Diseases of the Colon and Rectum, 44 (11). pp. 1585-9. ISSN 0012-3706

Full text not available from this repository. (Request a copy)

Abstract

Bile has been implicated in the pathogenesis of duodenal polyps in patients with familial adenomatous polyposis. In vitro experiments have shown that familial adenomatous polyposis bile is capable of producing DNA adducts. This effect can be ameliorated by increasing the pH of the incubate. The aim of this double-blind randomized placebo-controlled trial was to examine the effect of oral ranitidine on duodenal polyposis in a group of patients with familial adenomatous polyposis.

Item Type: Article
Uncontrolled Keywords: adenomatous polyposis coli,administration, oral,adult,anti-ulcer agents,bile,dna adducts,double-blind method,duodenal neoplasms,endoscopy,female,gastric acid,humans,intestinal polyps,male,ranitidine,treatment outcome
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Nutrition
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 11:58
Last Modified: 25 Jul 2018 09:54
URI: https://ueaeprints.uea.ac.uk/id/eprint/49578
DOI:

Actions (login required)

View Item