Expression of syndecan-1 in inflammatory bowel disease and a possible mechanism of heparin therapy

Day, R, Ilyas, M, Daszak, P, Talbot, I and Forbes, A (1999) Expression of syndecan-1 in inflammatory bowel disease and a possible mechanism of heparin therapy. Digestive Diseases and Sciences, 44 (12). pp. 2508-15. ISSN 0163-2116

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Abstract

Heparin apparently aids healing in ulcerative colitis although its mechanism of action is unknown. The purpose of this study was to investigate the hypothesis that heparin functions as a coreceptor molecule for basic fibroblast growth factor, a role usually performed by heparan sulfate chains on syndecan-1. A marked reduction of syndecan-1 immunostaining was found in reparative epithelium from inflammatory bowel disease patients. Removal of heparan sulfate on gastrointestinal epithelial cells in vitro reduced the proliferative response to basic fibroblast growth factor. The response to basic fibroblast growth factor was completely restored by the addition of heparin. Loss of syndecan-1 expression occurs in the regenerative mucosa in inflammatory bowel disease. Although this may facilitate tissue motility, its loss probably adversely affects the ability of cells to bind basic fibroblast growth factor. The present data show that heparin may substitute the loss of functional activity of syndecan-1 in the binding of basic fibroblast growth factor.

Item Type: Article
Uncontrolled Keywords: cells, cultured,colitis, ulcerative,crohn disease,epithelial cells,fibroblast growth factor 2,heparin,heparitin sulfate,humans,inflammatory bowel diseases,intestinal mucosa,membrane glycoproteins,proteoglycans,syndecan-1,syndecans
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 11:40
Last Modified: 11 Apr 2019 15:40
URI: https://ueaeprints.uea.ac.uk/id/eprint/49567
DOI:

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