Natural history of AIDS related sclerosing cholangitis:a study of 20 cases

Forbes, A, Blanshard, C and Gazzard, B (1993) Natural history of AIDS related sclerosing cholangitis:a study of 20 cases. Gut, 34 (1). pp. 116-21. ISSN 0017-5749

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Abstract

A case control study of AIDS related sclerosing cholangitis indicates that it has no overall influence on prognosis, but is responsible for a striking reversal of the usual inverse correlation of age and survival in HIV infection. Pain, the principal symptom, was controlled in surviving patients with analgesics alone. Twenty consecutive patients with AIDS related sclerosing cholangitis, defined from at least two characteristic lesions at endoscopic retrograde cholangiopancreatography, were followed for a minimum of 10 months or until death. Median age was 33.5 years (range 27-50). All had abdominal pain; 11 had diarrhoea. Alkaline phosphatase was > 2X normal in 13, but the bilirubin was raised in only three. The median CD4 was 0.024 x 10(9)/l (0.005-0.341). Thirteen had cryptosporidiosis, six had active cytomegalovirus, five had no gastrointestinal pathogen. Three patients are alive without AIDS related sclerosing cholangitis symptoms at 10, 11, and 21 months. Seventeen have died at median 7 (1-23) months. Cytomegalovirus therapy had no apparent influence. The initial CD4 was

Item Type: Article
Uncontrolled Keywords: acquired immunodeficiency syndrome,adult,age factors,case-control studies,cholangiopancreatography, endoscopic retrograde,cholangitis, sclerosing,cryptosporidiosis,cytomegalovirus infections,humans,male,middle aged,opportunistic infections,prognosis,survival rate
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Nutrition
Depositing User: Pure Connector
Date Deposited: 06 Aug 2014 11:44
Last Modified: 25 Jul 2018 09:53
URI: https://ueaeprints.uea.ac.uk/id/eprint/49536
DOI:

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