Increases in the concentrations of available iron in response to dietary iron supplementation are associated with changes in crypt cell proliferation in rat large intestine

Lund, Elizabeth K. ORCID: https://orcid.org/0000-0002-3269-3222, Wharf, S. Gabrielle, Fairweather-Tait, Susan J. ORCID: https://orcid.org/0000-0002-1413-5569 and Johnson, Ian T. (1998) Increases in the concentrations of available iron in response to dietary iron supplementation are associated with changes in crypt cell proliferation in rat large intestine. Journal of Nutrition, 128 (2). pp. 175-179. ISSN 0022-3166

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Abstract

High concentrations of iron in the diet have been shown to increase chemically induced colorectal tumors in rats. It is therefore important to understand the influence of dietary iron on the concentration of unabsorbed iron in the large intestine and its distribution between soluble and insoluble pools in the luminal compartment. We sought to investigate this issue and to establish whether iron modifies mucosal cell proliferation, which is thought to influence initiation and progression through the adenoma carcinoma sequence. In the first experiment, four groups of seven rats were fed diets at two concentrations of iron, 29 and 102 mg/kg, with or without the addition of 2.5 g phytic acid/kg. The concentrations of iron in the contents of the large bowel extractable with water ("free iron") or a buffered EDTA solution ("exchangeable iron") were determined. The concentration of freely soluble iron increased approximately 100% with iron supplementation in both the cecum and the colon, and there was an approximately five- to sixfold increase in exchangeable iron at both sites (P

Item Type:	Article
Uncontrolled Keywords:	animals,biological availability,cell division,colon,dose-response relationship, drug,intestine, large,iron, dietary,liver,male,organ size,phytic acid,rats,rats, wistar,tissue distribution
Faculty \ School:	Faculty of Science > School of Biological Sciences Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User:	Pure Connector
Date Deposited:	05 Aug 2014 12:24
Last Modified:	19 Oct 2023 01:19
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49199
DOI:	10.1093/jn/128.2.175

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