Health implications of iron overload: the role of diet and genotype

Heath, Anne-Louise M and Fairweather-Tait, Susan J ORCID: https://orcid.org/0000-0002-1413-5569 (2003) Health implications of iron overload: the role of diet and genotype. Nutrition Reviews, 61 (2). pp. 45-62. ISSN 0029-6643

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Abstract

The relationship between high dietary iron intake, mutations of the HFE gene, and iron status, and their effects on human health are reviewed. Prolonged high dietary intakes of iron are unlikely to result in iron overload in the general population. Homozygotes for the C282Y mutation of the HFE gene have elevated body iron levels. Heterozygotes have normal iron stores but some may be at increased risk for cardiovascular disease. There is no convincing evidence that elevated iron status increases the risk of coronary heart disease or type 2 diabetes, but high iron intakes may increase the risk of colorectal cancer. The dietary levels of iron associated with health risks in different HFE genotypes must be determined.

Item Type:	Article
Uncontrolled Keywords:	adult,aged,colorectal neoplasms,coronary disease,diabetes mellitus, type 2,female,humans,iron overload,iron, dietary,male,middle aged,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User:	Pure Connector
Date Deposited:	05 Aug 2014 12:20
Last Modified:	19 Oct 2023 01:19
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49187
DOI:	10.1301/nr.2003.febr.45-62

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