Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic-steatohepatitis in mice

Kroy, Daniela C, Schumacher, Fabienne, Ramadori, Pierluigi, Hatting, Maximilian, Bergheim, Ina, Gassler, Nikolaus, Boekschoten, Mark V, Müller, Michael ORCID: https://orcid.org/0000-0002-5930-9905, Streetz, Konrad L and Trautwein, Christian (2014) Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic-steatohepatitis in mice. Journal of Hepatology, 61 (4). 883–890. ISSN 0168-8278

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Abstract

Non-alcoholic-fatty-liver disease (NAFLD) is part of the metabolic syndrome. The spectrum of NAFLD includes NASH (non-alcoholic steatohepatitis), which is characterized by progressive inflammation associated with oxidative stress and apoptosis finally triggering liver cirrhosis and hepatocellular carcinoma. HGF (hepatocyte growth factor)/mesenchymal-epithelial transition factor (c-Met) receptor signaling is known to activate distinct intracellular pathways mediating among others anti-apoptotic properties to hepatocytes. Therefore, the aim was to characterize the role of c-met during NASH development.

Item Type:	Article
Additional Information:	Copyright © 2014. Published by Elsevier B.V.
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	Pure Connector
Date Deposited:	07 Jul 2014 14:02
Last Modified:	24 Oct 2022 06:28
URI:	https://ueaeprints.uea.ac.uk/id/eprint/49006
DOI:	10.1016/j.jhep.2014.05.019

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