Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

Kiesslich, R, Duckworth, C A, Moussata, D, Gloeckner, A, Lim, L G, Goetz, M, Pritchard, D M, Galle, P R, Neurath, M F and Watson, A J M (2012) Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. Gut, 61 (8). pp. 1146-1153. ISSN 0017-5749

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Abstract

Loss of intestinal barrier function plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is a potential cause of barrier loss during inflammation. The objectives of the study were (1) to determine whether cell shedding and barrier loss in humans can be detected by confocal endomicroscopy and (2) whether these parameters predict relapse of IBD.

Item Type: Article
Uncontrolled Keywords: adult,disease progression,endoscopy, gastrointestinal,female,fluorescein,fluorescent dyes,humans,inflammatory bowel diseases,intestinal mucosa,male,microscopy, confocal,middle aged,pilot projects,predictive value of tests,prognosis,prospective studies,recurrence
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 07 Jul 2014 14:44
Last Modified: 19 Sep 2018 14:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/48954
DOI: 10.1136/gutjnl-2011-300695

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