An unmet medical need:advances in endoscopic imaging of colorectal neoplasia

Stallmach, Andreas, Schmidt, Carsten, Watson, Alastair and Kiesslich, Ralf (2011) An unmet medical need:advances in endoscopic imaging of colorectal neoplasia. Journal of Biophotonics, 4 (7-8). pp. 482-489. ISSN 1864-0648

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    Abstract

    Gastrointestinal cancer is a major public health problem worldwide. Detection of early neoplastic lesions in gastrointestinal tract is essential for cure, because prognosis and survival are related to the size and stage of malignant lesions. Endoscopic screening and treatment of polyps could prevent approximately 80% of colorectal cancer (CRC). However, white-light endoscopy is an imperfect technology since miss rates of up to 25% have been reported and polyps without malignant potential were treated without benefit but with additional costs and risks to the patient. There are several known "human" predictors of an inadequate colonoscopy. These include patient characteristics such as poor bowel preparation, female gender, or inpatient status. Skills of the endoscopists are also an important issue. Therefore, a variety of advanced technologies has been attempted to overcome these issues. These new endoscopic imaging techniques allow a more precise classification of mucosal alterations with selection of patients for invasive therapy or surveillance. Further, molecular and functional imaging techniques could identify novel targets for therapies and new prospects to access response to therapies. However, at the "end of the day" a better endoscopic approach for CRC screening and surveillance depends on a good bowel preparation, a trained endoscopist spending sufficient time on a detailed examination together with an advanced endoscope.

    Item Type: Article
    Additional Information: Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Uncontrolled Keywords: animals,colorectal neoplasms,endoscopy, gastrointestinal,humans,microscopy,molecular imaging,physicians
    Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
    University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
    Depositing User: Pure Connector
    Date Deposited: 07 Jul 2014 14:42
    Last Modified: 25 Jul 2018 09:45
    URI: https://ueaeprints.uea.ac.uk/id/eprint/48950
    DOI: 10.1002/jbio.201100027

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