Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids

Kersten, Sander, Lichtenstein, Laeticia, Steenbergen, Emma, Mudde, Karin, Hendriks, Henk F J, Hesselink, Matthijs K, Schrauwen, Patrick and Müller, Michael (2009) Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids. Arteriosclerosis, Thrombosis, and Vascular Biology, 29 (6). pp. 969-974. ISSN 1079-5642

Full text not available from this repository. (Request a copy)

Abstract

Plasma lipoprotein levels are determined by the balance between lipoprotein production and clearance. Recently, angiopoietin-like protein 4 (ANGPTL4) was uncovered as a novel endocrine factor that potently raises plasma triglyceride levels by inhibiting triglyceride clearance. However, very little is known about ANGPTL4 in human. Here we set out to identify physiological determinants of plasma ANGPTL4 levels in humans, focusing on the effect of energy restriction and plasma FFAs.

Item Type: Article
Uncontrolled Keywords: adrenergic beta-agonists,adult,albuterol,angiopoietins,animals,caloric restriction,cells, cultured,enzyme-linked immunosorbent assay,exercise,fat emulsions, intravenous,fatty acids, nonesterified,humans,hypolipidemic agents,intestines,liver neoplasms,male,mice,middle aged,myocytes, cardiac,rna, messenger,rats,time factors,transfection,up-regulation,young adult
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 21 Feb 2014 11:56
Last Modified: 21 Mar 2019 11:09
URI: https://ueaeprints.uea.ac.uk/id/eprint/47705
DOI: 10.1161/ATVBAHA.108.182147

Actions (login required)

View Item