c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile duct ligation in mice

Giebeler, Arne, Boekschoten, Mark V, Klein, Christian, Borowiak, Malgorzata, Birchmeier, Carmen, Gassler, Nikolaus, Wasmuth, Hermann E, Müller, Michael, Trautwein, Christian and Streetz, Konrad L (2009) c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile duct ligation in mice. Gastroenterology, 137 (1). pp. 297-308. ISSN 0016-5085

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Abstract

The hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-Met) system is an essential inducer of hepatocyte growth and proliferation. Although a fundamental role for the HGF receptor c-Met has been shown in acute liver regeneration, its cell-specific role in hepatocytes during chronic liver injury and fibrosis progression has not been determined.

Item Type: Article
Uncontrolled Keywords: animals,apoptosis,cell proliferation,cholestasis, extrahepatic,chronic disease,common bile duct,cytokines,disease models, animal,disease progression,extracellular matrix proteins,gene expression profiling,hepatic stellate cells,hepatitis,hepatocyte growth factor,hepatocytes,inflammation mediators,ligation,liver,liver cirrhosis,mice,mice, knockout,necrosis,neutrophil infiltration,oligonucleotide array sequence analysis,proto-oncogene proteins c-met,time factors
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 21 Feb 2014 11:58
Last Modified: 02 Oct 2018 12:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/47703
DOI: 10.1053/j.gastro.2009.01.068

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