Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor

Rendeiro, Catarina, Vauzour, David, Rattray, Marcus, Waffo-Téguo, Pierre, Mérillon, Jean Michel, Butler, Laurie T, Williams, Claire M and Spencer, Jeremy P E (2013) Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor. PLoS ONE, 8 (5). ISSN 1932-6203

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Abstract

Evidence suggests that flavonoid-rich foods are capable of inducing improvements in memory and cognition in animals and humans. However, there is a lack of clarity concerning whether flavonoids are the causal agents in inducing such behavioral responses. Here we show that supplementation with pure anthocyanins or pure flavanols for 6 weeks, at levels similar to that found in blueberry (2% w/w), results in an enhancement of spatial memory in 18 month old rats. Pure flavanols and pure anthocyanins were observed to induce significant improvements in spatial working memory (p = 0.002 and p = 0.006 respectively), to a similar extent to that following blueberry supplementation (p = 0.002). These behavioral changes were paralleled by increases in hippocampal brain-derived neurotrophic factor (R = 0.46, p

Item Type: Article
Additional Information: © 2013 Rendeiro et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Uncontrolled Keywords: animals,anthocyanins,blueberry plant,body weight,brain-derived neurotrophic factor,diet,feeding behavior,flavonoids,gene expression regulation,hippocampus,male,memory,plant extracts,rna, messenger,rats,rats, wistar
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 27 Jan 2014 13:58
Last Modified: 25 Jul 2018 09:27
URI: https://ueaeprints.uea.ac.uk/id/eprint/47311
DOI: 10.1371/journal.pone.0063535

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