Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia

Palus, Sandra, von Haehling, Stephan, Flach, Valerie C, Tschirner, Anika, Doehner, Wolfram, Anker, Stefan D and Springer, Jochen (2013) Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia. International Journal of Cardiology, 168 (4). pp. 3412-8. ISSN 1874-1754

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Abstract

Chronic inflammation is common in cancer cachexia (CC) and directly involved in the atrophy seen in this condition. Recently, several groups have described a form of cardiomyopathy in CC animal models. Hence, we investigated the effect of simvastatin with its known anti-inflammatory and cardioprotective effects in a rat model of CC.

Item Type: Article
Additional Information: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User: Pure Connector
Date Deposited: 24 Jan 2014 12:48
Last Modified: 25 Jul 2018 09:19
URI: https://ueaeprints.uea.ac.uk/id/eprint/46783
DOI: 10.1016/j.ijcard.2013.04.150

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