Pharmacokinetics of drugs in cachectic patients:a systematic review

Trobec, Katja, Kerec Kos, Mojca, von Haehling, Stephan, Springer, Jochen, Anker, Stefan D and Lainscak, Mitja (2013) Pharmacokinetics of drugs in cachectic patients:a systematic review. PLoS ONE, 8 (11). ISSN 1932-6203

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Abstract

Cachexia is a weight-loss process caused by an underlying chronic disease such as cancer, chronic heart failure, chronic obstructive pulmonary disease, or rheumatoid arthritis. It leads to changes in body structure and function that may influence the pharmacokinetics of drugs. Changes in gut function and decreased subcutaneous tissue may influence the absorption of orally and transdermally applied drugs. Altered body composition and plasma protein concentration may affect drug distribution. Changes in the expression and function of metabolic enzymes could influence the metabolism of drugs, and their renal excretion could be affected by possible reduction in kidney function. Because no general guidelines exist for drug dose adjustments in cachectic patients, we conducted a systematic search to identify articles that investigated the pharmacokinetics of drugs in cachectic patients.

Item Type: Article
Additional Information: © 2013 Trobec et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User: Pure Connector
Date Deposited: 24 Jan 2014 12:42
Last Modified: 25 Jul 2018 09:19
URI: https://ueaeprints.uea.ac.uk/id/eprint/46778
DOI: 10.1371/journal.pone.0079603

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