Early onset Morganella morganii sepsis in a newborn infant with emergence of cephalosporin resistance caused by depression of AMPC beta-lactamase production.

Sinha, Ajay K, Kempley, Stephen T, Price, Elizabeth, Sharma, Bal K and Livermore, David M (2006) Early onset Morganella morganii sepsis in a newborn infant with emergence of cephalosporin resistance caused by depression of AMPC beta-lactamase production. Pediatric Infectious Disease Journal, 25 (4). pp. 376-7. ISSN 0891-3668

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Abstract

A preterm infant with early onset Morganella morganii sepsis was treated with cefotaxime and gentamicin after confirmation of antimicrobial susceptibility. The infant developed persistent ventriculitis caused by the emergence of a cefotaxime-resistant Morganella variant with derepression of its AmpC beta-lactamase. When choosing antibiotic therapy, the risk of development of resistance to cephalosporins should be considered in infections caused by M. morganii and other Gram-negative organisms with inducible AmpC beta-lactamases.

Item Type: Article
Uncontrolled Keywords: bacteremia,bacterial proteins,cefotaxime,cephalosporin resistance,enterobacteriaceae infections,female,humans,infant, newborn,infant, premature,infant, premature, diseases,meningitis, bacterial,microbial sensitivity tests,morganella morganii,beta-lactamases
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 24 Jan 2014 12:56
Last Modified: 21 Mar 2019 11:06
URI: https://ueaeprints.uea.ac.uk/id/eprint/46724
DOI: 10.1097/01.inf.0000207474.25593.2d

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