Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss

Gülmez, Dolunay, Woodford, Neil, Palepou, Marie-France I, Mushtaq, Shazad, Metan, Gokhan, Yakupogullari, Yusuf, Kocagoz, Sesin, Uzun, Omrum, Hascelik, Gulsen and Livermore, David M ORCID: https://orcid.org/0000-0002-9856-3703 (2008) Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss. International Journal of Antimicrobial Agents, 31 (6). pp. 523-6. ISSN 0924-8579

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Abstract

Treatment options are limited in infections caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae, with carbapenems generally preferred. Disturbingly, however, carbapenem-resistant strains are emerging worldwide. Here we report two clinical isolates, one Escherichia coli and one Klebsiella pneumoniae, each with high-level carbapenem resistance (imipenem minimum inhibitory concentration of 32 microg/mL). They were isolated following imipenem therapy from two hospital patients who had received imipenem therapy in different regions of Turkey. Both isolates produced OXA-48-like carbapenemases, enzymes so far reported only from Turkey. Both isolates also had group 1 CTX-M-type ESBLs and had lost major outer membrane proteins. OXA-48-like carbapenemases appear to be scattered in Turkey and surveillance to determine their prevalence is warranted.

Item Type:	Article
Uncontrolled Keywords:	anti-bacterial agents,bacterial outer membrane proteins,carbapenems,dna, bacterial,drug resistance, bacterial,escherichia coli,escherichia coli infections,female,humans,klebsiella infections,klebsiella pneumoniae,male,microbial sensitivity tests,middle aged,porins,reverse transcriptase polymerase chain reaction,transformation, bacterial,turkey,beta-lactam resistance,beta-lactamases,beta-lactams
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Pure Connector
Date Deposited:	06 Jan 2014 15:34
Last Modified:	24 Oct 2022 05:46
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46705
DOI:	10.1016/j.ijantimicag.2008.01.017

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