Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis

Jennings, Barbara Anne, Kwok, Chun Shing, Willis, Gavin, Matthews, Victoria, Wawruch, Pawel and Loke, Yoon Kong (2012) Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis. Pharmacogenetics and Genomics, 22 (4). pp. 290-304. ISSN 1744-6880

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Abstract

Many primary studies have considered the association of polymorphisms of folate metabolism and response to 5-fluorouracil (5-FU) and capecitabine in patients with colorectal cancer. The conclusions from these studies have been conflicting and few have considered large cohorts of patients. Therefore, we have completed a systematic review and meta-analyses to summarize some of the findings to date. We conducted searches for any studies that had addressed the prognostic value of genotype analysis of thymidylate synthetase (TYMS), Methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR).

Item Type: Article
Uncontrolled Keywords: colorectal neoplasms,databases, genetic,deoxycytidine,fluorouracil,folic acid,gene expression regulation, neoplastic,genetic association studies,genetic variation,genotype,humans,methylenetetrahydrofolate reductase (nadph2),tetrahydrofolate dehydrogenase,thymidylate synthase
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Biological Sciences
Depositing User: Pure Connector
Date Deposited: 20 Jan 2014 16:48
Last Modified: 23 Jan 2019 13:49
URI: https://ueaeprints.uea.ac.uk/id/eprint/46602
DOI: 10.1097/FPC.0b013e328351875d

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