The protozoan pathogen Toxoplasma gondii targets the paracellular pathway to invade the intestinal epithelium

Weight, Caroline M and Carding, Simon R (2012) The protozoan pathogen Toxoplasma gondii targets the paracellular pathway to invade the intestinal epithelium. Annals of the New York Academy of Sciences, 1258. pp. 135-42. ISSN 0077-8923

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Abstract

Abstract Toxoplasma gondii is a ubiquitous parasite found within all mammals and birds worldwide that can cause fatal infections in immunocompromised persons and fetuses. The parasite causes chronic infections by residing in long-living tissues of the muscle and brain. T. gondii infects the host through contaminated meat and water consumption with the gastrointestinal tract (GI tract) being the first point of contact with the host. The mechanisms by which the parasite invades the host through the GI tract are unknown, although it has been suggested that the paracellular pathway is important for parasite dissemination. Studies indicate that epithelial tight junction-associated proteins are affected by T. gondii, although which junctional proteins are affected and the nature of host protein-parasite interactions have not been established. We have uncovered evidence that T. gondii influences the cellular distribution of occludin to transmigrate the intestinal epithelium and suggest how candidate binding partners can be identified.

Item Type: Article
Additional Information: © 2012 New York Academy of Sciences.
Uncontrolled Keywords: animals,intestinal mucosa,toxoplasma
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 06 Jan 2014 15:40
Last Modified: 21 Mar 2019 11:03
URI: https://ueaeprints.uea.ac.uk/id/eprint/45989
DOI: 10.1111/j.1749-6632.2012.06534.x

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