Regular statin and aspirin use in patients with Barrett's oesophagus is associated with a reduced incidence of oesophageal adenocarcinoma

Beales, Ian L P, Vardi, Inna and Dearman, Leanne (2012) Regular statin and aspirin use in patients with Barrett's oesophagus is associated with a reduced incidence of oesophageal adenocarcinoma. European Journal of Gastroenterology & Hepatology, 24 (8). pp. 917-23. ISSN 0954-691X

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Abstract

Oesophageal adenocarcinoma (OAC) has a poor prognosis, and chemoprevention is an attractive option to reduce the burden of the disease. Hydroxyl-methyl-CoA reductase inhibitors (statins) have been shown to exert potentially useful anticancer effects against OAC cell lines, but there are only limited clinical data examining the effects of statins on the incidence of OAC.

Item Type: Article
Uncontrolled Keywords: adenocarcinoma,aged,aged, 80 and over,anti-inflammatory agents, non-steroidal,aspirin,barrett esophagus,case-control studies,dose-response relationship, drug,drug therapy, combination,esophageal neoplasms,female,humans,hydroxymethylglutaryl-coa reductase inhibitors,incidence,male,middle aged
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User: Pure Connector
Date Deposited: 16 Dec 2013 15:12
Last Modified: 25 Jul 2018 09:10
URI: https://ueaeprints.uea.ac.uk/id/eprint/45969
DOI: 10.1097/MEG.0b013e3283543f01

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