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ToolsViggars, Andrew P, Wharton, Stephen B, Simpson, Julie E, Matthews, Fiona E, Brayne, Carol, Savva, George M, Garwood, Claire, Drew, David, Shaw, Pamela J and Ince, Paul G (2011) Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology:a study in the MRC-CFAS population neuropathology cohort. Neuroscience Letters, 505 (1). pp. 25-30. ISSN 0304-3940
Full text not available from this repository.Abstract
Impairment of the blood brain barrier (BBB) in human brain ageing and its relationship to Alzheimer-type pathology remains poorly defined. We have investigated the BBB in temporal cortex of brain donations from a population-representative sample of 92 participants from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS), a longitudinal study with a programme of brain donation. BBB alteration was investigated by immunohistochemistry to albumin and fibrinogen and to the tight junction proteins claudin-5, zonula occludens-1 (ZO-1) and occludin. BBB leakage showed wide population-variation and increased with progression of Alzheimer-type pathology, though with considerable overlap between different levels of Alzheimer-type pathology. This was accompanied by increased mean vascular density, but not by down-regulation of tight junction proteins. ZO-1 and occludin were also expressed in glia. Mechanisms leading to BBB leakage in brain ageing remain to be defined, but the population-variation in BBB changes and its early increase in relationship to Alzheimer-type pathology progression suggest that BBB dysfunction contributes to brain ageing.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
| Uncontrolled Keywords: | aged,aged, 80 and over,aging,albumins,blood-brain barrier,cerebral cortex,claudin-5,claudins,cohort studies,collagen type iv,disease progression,down-regulation,female,fibrinogen,humans,male,membrane proteins,occludin,phosphoproteins,statistics, nonparametric,zonula occludens-1 protein |
| Faculty \ School: | |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Health in Later Life (former - to 2017) Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre |
| Depositing User: | Pure Connector |
| Date Deposited: | 09 Dec 2013 15:08 |
| Last Modified: | 04 Dec 2023 01:38 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/44926 |
| DOI: | 10.1016/j.neulet.2011.09.049 |
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