Denatured muscle grafts for nerve repair. An experimental model of nerve damage in leprosy

Pereira, J.H., Cowley, S.A., Gschmeissner, S.E., Bowden, R.E.M. and Turk, J.L. (1990) Denatured muscle grafts for nerve repair. An experimental model of nerve damage in leprosy. Journal of Bone and Joint Surgery - British Volume, 72 (5). pp. 874-880. ISSN 0301-620X

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Abstract

About 20% of patients with leprosy develop localised granulomatous lesions in peripheral nerves. We report experiments in guinea-pigs in which freeze-thawed autogenis muscle grafts were used for the treatment of such mycobacterial granulomas. Granulomas were induced in guinea-pig tibial nerves and the animals were left for 7 to 100 days in order to assess maximal damage. The local area of nerve damage was then excised and the gap filled with denatured muscle grafts. Clinical assessment after periods up to 150 days showed good sensory and motor recovery which correlated well with the histological findings. The muscle graft technique may be of value for the treatment of chronic nerve lesions in selected cases of leprosy.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 08 Nov 2013 12:40
Last Modified: 25 Jul 2018 08:48
URI: https://ueaeprints.uea.ac.uk/id/eprint/44289
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