Rhenium(I) phenanthrolines bearing electron withdrawing CF3 substituents: synthesis, characterization and biological evaluation

Redshaw, Carl, Watkins, Scott, Humphrey, Simon M., Bulman Page, Philip C., Ashby, Shane, Chao, Yimin, Herbert, Christopher J. and Mueller, Anja (2013) Rhenium(I) phenanthrolines bearing electron withdrawing CF3 substituents: synthesis, characterization and biological evaluation. RSC Advances, 3 (46). pp. 23963-23966. ISSN 2046-2069

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Abstract

Rhenium(I) tricarbonyl complexes bearing a 2,4,7,9-tetraphenylphenanthroline ligand, where the 2,9-phenyl groups have either meta- or para-CF3 groups, have been screened against a selection of cell lines. The meta derivative shows anticancer activity against HeLa and A549 cell lines, whereas the para derivative causes proliferation of HL-60 cells, whilst showing toxicity towards A549 cells.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
University of East Anglia > Faculty of Science > Research Groups > Synthetic Chemistry
University of East Anglia > Faculty of Science > Research Groups > Physical and Analytical Chemistry
Faculty of Science > School of Pharmacy
University of East Anglia > Faculty of Science > Research Groups > Pharmaceutical Cell Biology
Depositing User: Pure Connector
Date Deposited: 06 Nov 2013 12:22
Last Modified: 25 Jul 2018 08:48
URI: https://ueaeprints.uea.ac.uk/id/eprint/44275
DOI: 10.1039/c3ra43207f

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