Saturation transfer difference (STD) NMR spectroscopy characterization of dual binding mode of a mannose disaccharide to DC-SIGN

Angulo, Jesus, Díaz, Irene, Reina, Jose J., Tabarani, Georges, Fieschi, Franck, Rojo, Javier and Nieto, Pedro M. (2008) Saturation transfer difference (STD) NMR spectroscopy characterization of dual binding mode of a mannose disaccharide to DC-SIGN. ChemBioChem, 9 (14). pp. 2225-2227. ISSN 1439-4227

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Abstract

Concurrent multiple binding modes of a single ligand can be detected and quantified by saturation transfer difference (STD) NMR spectroscopy. Analysis of experimental and predicted STD initial growing rates has allowed us to determine the precise orientation of Man a(1?2)Man in the minor complex with the carbohydrate recognition domain of DC-SIGN.

Item Type: Article
Uncontrolled Keywords: dc-sign,mannose,molecualr recognition,nmr spectroscopy,std-nmr
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: Pure Connector
Date Deposited: 21 Oct 2013 22:40
Last Modified: 06 Dec 2018 15:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/43749
DOI: 10.1002/cbic.200800361

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