Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile

Al-Jamal, Khuloud T, Nunes, Antonio, Methven, Laura, Ali-Boucetta, Hanene, Li, Shouping, Toma, Francesca M, Herrero, M Antonia, Al-Jamal, Wafa' T, ten Eikelder, Huub M M, Foster, Julie, Mather, Stephen, Prato, Maurizio, Bianco, Alberto and Kostarelos, Kostas (2012) Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile. Angewandte Chemie International Edition, 51 (26). pp. 6389-6393. ISSN 1433-7851

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Abstract

Getting rid of the tubes: An assessment of the retention of functionalized multi-walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation.

Item Type: Article
Additional Information: Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Uncontrolled Keywords: molecular structure,microscopy, electron, transmission,animals,models, molecular,organ specificity,mice,amines,nanotubes, carbon
Faculty \ School: Faculty of Science > School of Pharmacy
University of East Anglia > Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials
Depositing User: Pure Connector
Date Deposited: 05 Oct 2013 01:55
Last Modified: 25 Jul 2018 08:38
URI: https://ueaeprints.uea.ac.uk/id/eprint/43573
DOI: 10.1002/anie.201201991

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