Surface functionalisation techniques for colloidal inorganic nanocrystals

McNaughter, Paul D. (2013) Surface functionalisation techniques for colloidal inorganic nanocrystals. Doctoral thesis, University of East Anglia.

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    Abstract

    Colloidally-stable inorganic nanocrystals have a wide range of envisaged
    applications in biological environments. To reach their potential, the nanocrystals
    need to be stable in aqueous environments and have pendant functionality
    available for attachment of biomolecules. In this thesis, new methods for the
    transfer of nanocrystals from organic to aqueous media are developed and the
    interaction of aqueous stabilised particles with serum proteins is investigated.
    In Chapter 3, a new method for the synthesis of a thin silica layer upon the
    surface of nanocrystals is demonstrated. The method uses the hydrophobic interaction
    between an amphiphilic polymer and nanocrystal ligands to provide
    a foundation for growth of a silica layer. The coated nanocrystals are characterised
    using a wide range of techniques confirming that the presence and
    location of the silica shell.
    In Chapter 4, custom-synthesised amphiphilic polymers for water transfer
    and functionalisation of nanocrystals are synthesised, characterised and tested.
    Commercially-available polymers used for this purpose are examined, leading
    to a rationale for custom-design. Partial water transfers were achieved using
    activated ester copolymers with styrene but no transfers were achieved the
    octadecylacrylate copolymers. Poly(ethylene glycol) containing monomers
    were also used but yielded no transfers. This suggests that behaviour of the
    polymer during the coating procedure is intimately linked to the structure of
    the polymer.
    In Chapter 5, small-angle neutron scattering is used to elucidate structural
    information for the protein corona formed on nanocrystals and silica nanoparticles.
    Information on the packing of ligands on colloidal nanocrystals
    without a amphiphilic polymer coating was determined. The fitting of the
    protein corona upon silica nanoparticles was explored using core-shell form
    factors but was hampered by complexities within the scattering profiles which
    were not accounted for using simple form factors.

    Item Type: Thesis (Doctoral)
    Faculty \ School: Faculty of Science > School of Chemistry
    Depositing User: Brian Watkins
    Date Deposited: 29 Jul 2013 16:10
    Last Modified: 29 Jul 2013 16:24
    URI: https://ueaeprints.uea.ac.uk/id/eprint/43077
    DOI:

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