TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy

Baumgarten, Anna, Bang, Claudia, Tschirner, Anika, Engelmann, Anke, Adams, Volker, von Haehling, Stephan, Doehner, Wolfram, Pregla, Reinhard, Anker, Markus S, Blecharz, Kinga, Meyer, Rudolf, Hetzer, Roland, Anker, Stefan D, Thum, Thomas and Springer, Jochen (2013) TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy. International Journal of Cardiology, 168 (2). pp. 1447-52. ISSN 1874-1754

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Abstract

The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.

Item Type: Article
Additional Information: Copyright © 2013. Published by Elsevier Ireland Ltd.
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User: Jochen Springer
Date Deposited: 29 Apr 2013 15:29
Last Modified: 25 Jul 2018 03:14
URI: https://ueaeprints.uea.ac.uk/id/eprint/41634
DOI: 10.1016/j.ijcard.2012.12.094

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