Targeting the oncofetal Thomsen-Friedenreich disaccharide using Jacalin-PEG phthalocyanine gold nanoparticles for photodynamic cancer therapy

Obaid, Girgis, Chambrier, Isabelle, Cook, Michael J. and Russell, David A. (2012) Targeting the oncofetal Thomsen-Friedenreich disaccharide using Jacalin-PEG phthalocyanine gold nanoparticles for photodynamic cancer therapy. Angewandte Chemie-International Edition, 51 (25). pp. 6158-6162. ISSN 1521-3773

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Abstract

Light-sensitive: Targeted photodynamic therapy is achieved by using gold nanoparticles that are stabilized by a mixed monolayer of a hydrophobic zinc phthalocyanine photosensitizer, which produces cytotoxic singlet oxygen, and a water-soluble thiol-functionalized poly(ethylene glycol) carrying the lectin jacalin, which targets the Thomsen–Friedenreich disaccharide antigen at the surface of cancer cells.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Chemistry
UEA Research Groups:	Faculty of Science > Research Groups > Physical and Analytical Chemistry (former - to 2017)
Depositing User:	Users 2731 not found.
Date Deposited:	29 Oct 2012 16:06
Last Modified:	31 Mar 2024 00:46
URI:	https://ueaeprints.uea.ac.uk/id/eprint/40006
DOI:	10.1002/anie.201201468

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