Brassinosteroids inhibit pathogen-associated molecular pattern-triggered immune signaling independent of the receptor kinase BAK1

Albrecht, Catherine, Boutrot, Freddy, Segonzac, Cécile, Schwessinger, Benjamin, Gimenez-Ibanez, Selena, Chinchilla, Delphine, Rathjen, John P, de Vries, Sacco C and Zipfel, Cyril (2012) Brassinosteroids inhibit pathogen-associated molecular pattern-triggered immune signaling independent of the receptor kinase BAK1. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 109 (1). pp. 303-308. ISSN 0027-8424

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Abstract

Plants and animals use innate immunity as a first defense against pathogens, a costly yet necessary tradeoff between growth and immunity. In Arabidopsis, the regulatory leucine-rich repeat receptor-like kinase (LRR-RLK) BAK1 combines with the LRR-RLKs FLS2 and EFR in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and the LRR-RLK BRI1 in brassinosteroid (BR)-mediated growth. Therefore, a potential tradeoff between these pathways mediated by BAK1 is often postulated. Here, we show a unidirectional inhibition of FLS2-mediated immune signaling by BR perception. Unexpectedly, this effect occurred downstream or independently of complex formation with BAK1 and associated downstream phosphorylation. Thus, BAK1 is not rate-limiting in these pathways. BRs also inhibited signaling triggered by the BAK1-independent recognition of the fungal PAMP chitin. Our results suggest a general mechanism operative in plants in which BR-mediated growth directly antagonizes innate immune signaling.

Item Type: Article
Uncontrolled Keywords: arabidopsis,arabidopsis proteins,brassinosteroids,enzyme activation,flagellin,plant immunity,protein kinases,protein-serine-threonine kinases,pseudomonas,receptors, pattern recognition,signal transduction,steroids, heterocyclic
Faculty \ School: Faculty of Science > School of Biological Sciences
University of East Anglia > Faculty of Science > Research Groups > Plant Sciences
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Depositing User: Deborah Clemitshaw
Date Deposited: 21 Feb 2012 16:13
Last Modified: 25 Jul 2018 03:22
URI: https://ueaeprints.uea.ac.uk/id/eprint/37336
DOI: 10.1073/pnas.1109921108

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