Bacterial iron-sulfur regulatory proteins as biological sensor-switches

Crack, JC, Green, J, Hutchings, M, Thomson, AJ and Le Brun, NE (2012) Bacterial iron-sulfur regulatory proteins as biological sensor-switches. Antioxidants & Redox Signaling, 17. pp. 1215-1231. ISSN 1523-0864

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Abstract

Significance. In recent years, bacterial iron-sulfur cluster proteins that function as regulators of gene transcription have emerged as a major new group. In all cases, the cluster acts as a sensor of the environment and enables the organism to adapt to the prevailing conditions. This can range from mounting a response to oxidative or nitrosative stress to switching between anaerobic and aerobic respiratory pathways. The sensitivity of these ancient cofactors to small molecule reactive oxygen and nitrogen species, in particular, make them ideally suited to function as sensors. Recent Advances. An important challenge is to obtain mechanistic and structural information about how these regulators function and, in particular, how the chemistry occurring at the cluster drives the subsequent regulatory response. For several regulators, including FNR, SoxR, NsrR, IscR and Wbl proteins, major advances in understanding have been gained recently and these are reviewed here. Critical Issues. A common theme emerging from these studies is that the sensitivity and specificity of the cluster of each regulatory protein must be exquisitely controlled by the protein environment of the cluster. Future Directions. A major future challenge is to determine, for a range of regulators, the key factors for achieving control of sensitivity/specificity. Such information will lead, eventually, to a system understanding of stress response, which often involves more than one regulator.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
Faculty of Science > School of Chemistry
University of East Anglia > Faculty of Science > Research Groups > Biophysical Chemistry
University of East Anglia > Faculty of Science > Research Groups > Molecular Microbiology
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Depositing User: Deborah Clemitshaw
Date Deposited: 25 Jan 2012 14:17
Last Modified: 25 Jul 2018 03:25
URI: https://ueaeprints.uea.ac.uk/id/eprint/36492
DOI: 10.1089/ars.2012.4511

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