Robbins, Diane, Newton, Annabella F., Gignoux, Camille, Legeay, Jean-Christophe, Sinclair, Alex, Rejzek, Martin, Laxon, Carly A., Yalamanchili, Sai K., Lewis, William, O'Connell, Maria A. ORCID: https://orcid.org/0000-0002-0267-0951 and Stockman, Robert A.
(2011)
Synthesis of natural-product-like scaffolds in unprecedented efficiency via a 12-fold branching pathway.
Chemical Science, 11 (2).
pp. 2232-2235.
ISSN 2041-6539
Abstract
Tying the knot! The marriage of two-directional synthesis and tandem reactions allows access to twelve skeletally diverse scaffolds in just fifteen reactions. Two-directional synthesis yields a symmetrical linear “rope-like” keto-dienoate which is then subjected to twelve separate tandem reactions to “tie the rope in knots” thus creating twelve diverse natural product-like scaffolds containing useful functionality for further elaboration.
Item Type: | Article |
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Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
UEA Research Groups: | Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017) Faculty of Science > Research Groups > Molecular and Tissue Pharmacology |
Depositing User: | Users 2731 not found. |
Date Deposited: | 23 Aug 2011 12:43 |
Last Modified: | 22 Aug 2024 11:30 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/34588 |
DOI: | 10.1039/C1SC00371B |
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