Gammadelta T cells:functional plasticity and heterogeneity

Carding, Simon R and Egan, Paul J (2002) Gammadelta T cells:functional plasticity and heterogeneity. Nature Reviews Immunology, 2 (5). pp. 336-345. ISSN 1474-1733

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Abstract

Gammadelta T cells remain an enigma. They are capable of generating more unique antigen receptors than alphabeta T cells and B cells combined, yet their repertoire of antigen receptors is dominated by specific subsets that recognize a limited number of antigens. A variety of sometimes conflicting effector functions have been ascribed to them, yet their biological function(s) remains unclear. On the basis of studies of gammadelta T cells in infectious and autoimmune diseases, we argue that gammadelta T cells perform different functions according to their tissue distribution, antigen-receptor structure and local microenvironment; we also discuss how and at what stage of the immune response they become activated.

Item Type: Article
Uncontrolled Keywords: animals,autoantigens,autoimmune diseases,cell lineage,disease models, animal,genes, t-cell receptor,humans,immunologic surveillance,infection,mice,receptors, antigen, t-cell, gamma-delta,t-lymphocytes
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
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Depositing User: Rhiannon Harvey
Date Deposited: 14 Jul 2011 12:01
Last Modified: 25 Jul 2018 07:18
URI: https://ueaeprints.uea.ac.uk/id/eprint/33714
DOI: 10.1038/nri797

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