Delineation of the function of a major gamma delta T cell subset during infection

Andrew, Elizabeth M., Newton, Darren J., Dalton, Jane E., Egan, Charlotte E., Goodwin, Stewart J., Tramonti, Daniela, Scott, Philip and Carding, Simon R. (2005) Delineation of the function of a major gamma delta T cell subset during infection. Journal of Immunology, 175 (3). pp. 1741-1750. ISSN 0022-1767

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Abstract

Gammadelta T cells play important but poorly defined roles in pathogen-induced immune responses and in preventing chronic inflammation and pathology. A major obstacle to defining their function is establishing the degree of functional redundancy and heterogeneity among gammadelta T cells. Using mice deficient in Vgamma1+ T cells which are a major component of the gammadelta T cell response to microbial infection, a specific immunoregulatory role for Vgamma1+ T cells in macrophage and gammadelta T cell homeostasis during infection has been established. By contrast, Vgamma1+ T cells play no significant role in pathogen containment or eradication and cannot protect mice from immune-mediated pathology. Pathogen-elicited Vgamma1+ T cells also display different functional characteristics at different stages of the host response to infection that involves unique and different populations of Vgamma1+ T cells. These findings, therefore, identify distinct and nonoverlapping roles for gammadelta T cell subsets in infection and establish the complexity and adaptability of a single population of gammadelta T cells in the host response to infection that is not predetermined, but is, instead, shaped by environmental factors.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	Rhiannon Harvey
Date Deposited:	14 Jul 2011 10:44
Last Modified:	09 Aug 2023 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/33711
DOI:	10.4049/jimmunol.175.3.1741

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