Emerging Linezolid-Resistant Enterococcus faecalis and Enterococcus faecium Isolated from Two Austrian Patients in the Same Intensive Care Unit

Johnson, A, Tysall, L, Stockdale, M, Woodford, N, Kaufmann, M, Warner, M, Livermore, DM, Asboth, F and Allerberger, F (2002) Emerging Linezolid-Resistant Enterococcus faecalis and Enterococcus faecium Isolated from Two Austrian Patients in the Same Intensive Care Unit. European Journal of Clinical Microbiology & Infectious Diseases, 21 (10). pp. 751-754. ISSN 0934-9723

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Abstract

Of two patients in the same intensive care unit who were treated with linezolid, one yielded linezolid-resistant Enterococcus faecalis, whereas the other yielded linezolid-resistant Enterococcus faecium. In each case, molecular typing indicated that the resistant isolates were related to linezolid-susceptible isolates from the same patient, but differed from them by the same G2576U ribosomal RNA mutation. This is the first clinical case report of emerging resistance to linezolid among Enterococcus faecalis and also the first report of resistance involving vancomycin-susceptible rather than vancomycin-resistant enterococci. The linezolid-resistant isolates showed cross-resistance to the experimental oxazolidinone AZD2563, suggesting that oxazolidinone resistance might be a class effect.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: Rhiannon Harvey
Date Deposited: 11 Jul 2011 12:12
Last Modified: 23 Jan 2019 13:45
URI: https://ueaeprints.uea.ac.uk/id/eprint/33489
DOI: 10.1007/s10096-002-0807-0

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