Asymmetric epoxidation of cis-alkenes mediated by iminium salts: Highly enantioselective synthesis of levcromakalim

Bulman Page, P. C. B., Buckley, B. R., Heaney, H. and Blacker, A. J. (2005) Asymmetric epoxidation of cis-alkenes mediated by iminium salts: Highly enantioselective synthesis of levcromakalim. Organic Letters, 7 (3). pp. 375-377. ISSN 1523-7060

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Abstract

A range of cis-substituted olefins has been epoxidized with a new dihydroisoquinolinium salt catalyst, using tetraphenylphosphonium monoperoxysulfate as the stoichiometric oxidant, giving ee's of up to 97%. The reaction has been used as the key step in an enantioselertive synthesis of the antihypertensive agent levcromakalim.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry
UEA Research Groups:	Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemistry of Materials and Catalysis
Depositing User:	Rachel Smith
Date Deposited:	20 Jun 2011 15:10
Last Modified:	24 Oct 2022 02:15
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32867
DOI:	10.1021/ol047836h

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