Asymmetric epoxidation of cis-alkenes mediated by iminium salts: Highly enantioselective synthesis of levcromakalim

Bulman Page, P. C. B., Buckley, B. R., Heaney, H. and Blacker, A. J. (2005) Asymmetric epoxidation of cis-alkenes mediated by iminium salts: Highly enantioselective synthesis of levcromakalim. Organic Letters, 7 (3). pp. 375-377. ISSN 1523-7060

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Abstract

A range of cis-substituted olefins has been epoxidized with a new dihydroisoquinolinium salt catalyst, using tetraphenylphosphonium monoperoxysulfate as the stoichiometric oxidant, giving ee's of up to 97%. The reaction has been used as the key step in an enantioselertive synthesis of the antihypertensive agent levcromakalim.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
Depositing User: Rachel Smith
Date Deposited: 20 Jun 2011 16:10
Last Modified: 19 Nov 2018 14:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/32867
DOI: 10.1021/ol047836h

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