PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD

White, Helen D, Ahmad, Aftab M, Durham, Brian H, Peter, Rajesh, Prabhakar, V Karthik B, Corlett, Pamela, Vora, Jiten P and Fraser, WD (2007) PTH circadian rhythm and PTH target-organ sensitivity is altered in patients with adult growth hormone deficiency with low BMD. Journal of Bone and Mineral Research, 22 (11). pp. 1798-1807. ISSN 1523-4681

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Abstract

AGHD is associated with osteoporosis. We examined PTH circadian rhythmicity and PTH target-organ sensitivity in 23 patients with AGHD with low BMD and 20 patients with AGHD with normal BMD. Patients with low BMD had a blunted nocturnal rise in PTH concentration and reduced PTH target-organ sensitivity compared with patients with normal BMD; these factors may be important in the pathogenesis of AGHD-related osteoporosis.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine
Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User: Rhiannon Harvey
Date Deposited: 08 Jun 2011 13:42
Last Modified: 19 Oct 2023 00:45
URI: https://ueaeprints.uea.ac.uk/id/eprint/32073
DOI: 10.1359/jbmr.070715

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