Myositis in children with meningococcal disease: A role for tumour necrosis factor-α and interleukin-8?

Carrol, E. D., Thomas, A. P., Mobbs, K. J., Fraser, W. D. and Hart, C. A. (2002) Myositis in children with meningococcal disease: A role for tumour necrosis factor-α and interleukin-8? Journal of Infection, 44 (1). pp. 17-21. ISSN 1532-2742

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Abstract

Objectives: Myalgia is under-recognized in meningococcal disease (MCD). In septic shock, myositis is thought to be mediated by pro-inflammatory cytokines such as tumour necrosis factor-α (TNF-α), interleukin-8 (IL-8) and interleukin-6 (IL-6) but this has never previously been studied in MCD. We aimed to demonstrate whether muscle damage mediated via TNF-α and other pro-inflammatory cytokines occurs in MCD, as estimated by creatine kinase skeletal muscle isoenzyme (CK-MM) and cardiac isoenzyme (CK-MB) concentrations. Methods: A total of 68 children, median age 2.7 years, with a diagnosis of MCD were prospectively studied. Severity of disease was measured using the Glasgow Meningococcal Septicaemia Prognostic Score (GMSPS). Severe disease was defined as a GMSPS of ≥8. TNF-α, IL-8, IL-6 and IL-1Ra concentrations were determined on samples taken on admission. Results: CK-MM correlated significantly with TNF-α, IL-8 and GMSPS. There was no significant correlation between CK-MB and TNF-α or IL-6, but CK-MB correlated with GMSPS and IL-8. Fifty-six percent of children with MCD had evidence of muscle damage as manifested by elevated CK-MM. Conclusions: TNF-α and IL-8 may be potential mediators in the pathophysiology of skeletal muscle damage in MCD.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Rhiannon Harvey
Date Deposited:	07 Jun 2011 15:24
Last Modified:	24 Jan 2024 01:23
URI:	https://ueaeprints.uea.ac.uk/id/eprint/31953
DOI:	10.1053/jinf.2001.0923

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