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ToolsSung, Hye Youn, Guan, Hongtao, Czibula, Agnes, King, Andrea R., Eder, Katalin, Heath, Emily, Suvarna, S. Kim, Dower, Steven K., Wilson, Anthony G., Francis, Sheila E., Crossman, David C. and Kiss-Toth, Endre (2007) Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways. Journal of Biological Chemistry, 282 (25). pp. 18379-18387. ISSN 0021-9258
Full text not available from this repository.Abstract
Migration and proliferation of smooth muscle cells are key to a number of physiological and pathological processes, including wound healing and the narrowing of the vessel wall. Previous work has shown links between inflammatory stimuli and vascular smooth muscle cell proliferation and migration through mitogen-activated protein kinase (MAPK) activation, although the molecular mechanisms of this process are poorly understood. Here we report that tribbles-1, a recently described modulator of MAPK activation, controls vascular smooth muscle cell proliferation and chemotaxis via the Jun kinase pathway. Our findings demonstrate that this regulation takes place via direct interactions between tribbles-1 and MKK4/SEK1, a Jun activator kinase. The activity of this kinase is dependent on tribbles-1 levels, whereas the activation and the expression of MKK4/SEK1 are not. In addition, tribbles-1 expression is elevated in human atherosclerotic arteries when compared with non-atherosclerotic controls, suggesting that this protein may play a role in disease in vivo. In summary, the data presented here suggest an important regulatory role for trb-1 in vascular smooth muscle cell biology.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit |
| Depositing User: | Rhiannon Harvey |
| Date Deposited: | 18 May 2011 08:01 |
| Last Modified: | 30 Jun 2023 13:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/30728 |
| DOI: | 10.1074/jbc.M610792200 |
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