Practical synthesis of sugar monophosphonucleotides

Wlassoff, W. A., Finlay, R. M. J. and Hamilton, C. J. (2007) Practical synthesis of sugar monophosphonucleotides. Synthetic Communications, 37 (17). pp. 2927-2934. ISSN 0039-7911

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Abstract

A reliable procedure for the preparation of sugar nucleoside monophosphates is presented, which involves condensation of an activated glycosyl-1-H-phosphonate with an appropriately protected nucleoside and simple end-product isolation via lithium perchlorate-induced precipitation. The utility of these methods is demonstrated by the preparation of a number of purine- and pyrimidine-based sugar nucleoside monophosphate derivatives.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Rachel Smith
Date Deposited:	17 May 2011 15:51
Last Modified:	24 Oct 2022 01:35
URI:	https://ueaeprints.uea.ac.uk/id/eprint/30707
DOI:	10.1080/00397910701471543

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