Preliminary mu SR studies on the incorporation of steroidal drug molecules into liposomes

Barker, S. A., Cottrell, S. P., Giblin, S. R. and Jayasooriya, U. A. (2006) Preliminary mu SR studies on the incorporation of steroidal drug molecules into liposomes. Physica B: Condensed Matter, 374. pp. 332-335. ISSN 0921-4526

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Abstract

Muon spin relaxation of two liposome samples consisting of 100% DPPC (dipaimitoylphosphatidyleholine) and 50:50mole% DPPC: Cholesterol at a final lipid concentration of 100mg/mL are compared. The observation of a significant loss in the muonium fraction from 11% to 6% when cholesterol is present is compatible with radical formation in the second sample. Also reported are measurements on pure solid cholesterol where a clear T-1 minimum at ca 100K, corresponding to a dynamic process with activation energy of ca. 1.89 kJmol(-1) and an attempt frequency of 5.89 x 10(10) s(-1), is observed. An estimate of a hyperfine interaction of 255.4 MHz for this radical predicts a Delta M= 1 ALC transition at 0.94 T. (c) 2005 Elsevier B.V. All rights reserved.

Item Type: Article
Uncontrolled Keywords: liposomes,muonium,drug delivery,spin resonance,steroids
Faculty \ School: Faculty of Science > School of Pharmacy
Faculty of Science > School of Chemistry
Depositing User: Rachel Smith
Date Deposited: 11 May 2011 11:55
Last Modified: 12 Nov 2018 13:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/30231
DOI: 10.1016/j.physb.2005.11.089

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