Rofecoxib has different effects on chemokine production in colorectal cancer cells and tumor immune splenocytes

Walmesley, Alice J, Zweiri, Jehad, Christmas, Stephen E and Watson, Alastair J M (2007) Rofecoxib has different effects on chemokine production in colorectal cancer cells and tumor immune splenocytes. Journal of Immunotherapy, 30 (6). pp. 614-623. ISSN 1524-9557

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Abstract

Cyclooxygenase-2 (COX-2) is overexpressed in colon tumors. Its main product is the immunosuppressive prostaglandin PGE2 that aids tumor immune escape. In this study, we analyzed mechanisms of action of the COX-2 inhibitor rofecoxib on the immune response to colorectal cancer in an animal model. The murine colorectal cancer cell line MC26, and splenocytes from BALB/c mice immune to irradiated MC26 cells, were incubated with rofecoxib or PGE2. In MC26 cells, 100 nM rofecoxib caused a complete abrogation of PGE2 production and inhibited cell proliferation. Splenocytes from tumor immune mice showed a 300% (P

Item Type: Article
Uncontrolled Keywords: animals,cell line, tumor,cell proliferation,chemokines,colorectal neoplasms,cyclooxygenase 2,cyclooxygenase 2 inhibitors,dinoprostone,female,gene expression,lactones,mice,mice, inbred balb c,monocytes,spleen,sulfones
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
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Depositing User: Rhiannon Harvey
Date Deposited: 01 Apr 2011 10:13
Last Modified: 09 Aug 2018 12:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/27862
DOI: 10.1097/CJI.0b013e31805ca039

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