Cellular Uptake of a Fluorescent Calix[4]arene Derivative

Lalor, R, Baillie-Johnson, H, Redshaw, C, Matthews, SE and Mueller, A (2008) Cellular Uptake of a Fluorescent Calix[4]arene Derivative. Journal of the American Chemical Society, 130 (10). pp. 2892-2893.

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Abstract

A rapid synthetic route to a nontoxic fluorescently labeled water-soluble calixarene has been developed. Investigation of the cellular uptake of the labeled calixarene, via confocal microscopy, through coincubation with uptake inhibitors demonstrates that uptake is not through the common clathrin coated pits or caveolae (lipid raft) endocytic pathways and that the calixarene derivative localizes within the cytoplasm and does not enter the nucleus. The study demonstrates the power of fluorescent labeling for investigation of interactions between calixarenes and biological systems and the potential for calixarene based intracellular imaging agents.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Faculty of Science > School of Chemistry
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Depositing User: Rachel Smith
Date Deposited: 16 Mar 2011 16:19
Last Modified: 19 Sep 2018 15:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/26430
DOI: 10.1021/ja0782596

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