Expedient synthesis of substituted (diphenylphosphinoylmethyl)benzenes

Bew, S.P., Brimage, R.A., Hughes, D.L., Legentil, L., Sharma, S.V. and Wilson, M.A. (2007) Expedient synthesis of substituted (diphenylphosphinoylmethyl)benzenes. The Journal of Organic Chemistry, 72 (7). pp. 2655-2658.

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Abstract

An efficient protocol for the synthesis of structurally diverse (diphenylphosphinoylmethyl)benzenes is described. The reaction employs readily available carboxylic acids, chlorodiphenylphosphine, and water as the reagents. A 97% reduction in the reaction times and substantially higher yields of products result, up to a 60% increase, if the reactions are performed under microwave irradiation. The first examples of transition-metal-catalyzed reactions applied to 4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene are also reported. © 2007 American Chemical Society.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
University of East Anglia > Faculty of Science > Research Groups > Synthetic Chemistry
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Faculty of Science > School of Chemical Sciences and Pharmacy
Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Rachel Smith
Date Deposited: 15 Feb 2011 10:07
Last Modified: 25 Jul 2018 05:37
URI: https://ueaeprints.uea.ac.uk/id/eprint/21371
DOI: 10.1021/jo062114k

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