Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells

Burguete, MI, Galindo, F, Gavara, R, Luis, SV, Moreno, M, Thomas, P and Russell, DA (2009) Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells. Photochemical & Photobiological Sciences, 8 (1). pp. 37-44. ISSN 1474-905X

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Abstract

Photogeneration of singlet oxygen (1O2) by rose bengal is improved through the use of a porous monolithic polymer (PMP) as a support, as compared to a classic gel-type resin matrix. This type of monolithic polymeric matrix can be made at a multigram scale in quantitative yields enabling the preparation of large amounts of supported photosensitizer at low cost. The singlet oxygen induced oxidation of 9,10-diphenylanthracene has been used as a benchmark reaction, and a comparative study using rose bengal in solution, entrapped within gel-type derived polymer and entrapped within a porous monolithic polymer (PMP) has been performed. The enhanced photoreactivity of the PMP-rose bengal conjugates has been utilised for the successful photodynamic therapy (PDT) of melanoma cells.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
Related URLs:
Depositing User: Rachel Smith
Date Deposited: 24 Jan 2011 11:42
Last Modified: 21 Dec 2018 10:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/19723
DOI: 10.1039/b810921d

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