Screening for rectal cancer - Will it improve cure rates?

Tweedle, EM, Rooney, PS and Watson, AJM (2007) Screening for rectal cancer - Will it improve cure rates? Clinical Oncology, 19 (9). 639–648.

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Abstract

Here we give an overview of colorectal cancer screening strategies with an emphasis on the diagnosis and management of rectal cancer. We review the published studies on screening in the high-risk population, including patients with a history of colorectal cancer, inflammatory bowel disease and inherited conditions. In the average-risk population, the evidence base for a number of screening strategies is evaluated, including endoscopy, contrast studies and faecal occult blood testing. Screening guidelines in the high-risk population are predominantly based on case-control studies comparing the incidence of colorectal cancer in screened and control groups. Screening the average-risk population for colorectal cancer reduces cancer-specific mortality by 15% after biennial guaiac faecal occult blood testing and 50-80% after flexible sigmoidoscopy. All of the screening strategies outlined have a greater sensitivity for distal lesions than proximal lesions.

Item Type: Article
Uncontrolled Keywords: case-control studies,guidelines as topic,humans,mass screening,rectal neoplasms,risk factors
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
University of East Anglia > Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
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Depositing User: EPrints Services
Date Deposited: 25 Nov 2010 11:13
Last Modified: 25 Jul 2018 05:57
URI: https://ueaeprints.uea.ac.uk/id/eprint/15618
DOI: 10.1016/j.clon.2007.07.002

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